so i actually watched it. the result of the experiment was that he did marginally better at league of legends the second month, while on estrogen, but personally i think that playing hundreds of matches for a couple months probably had more to do with it. it is known that practice can improve one's skills, after all. the real takeaway of the video is that it can be pretty freaking hard to get estrogen.
The best way to draw a conclusion is to stop taking estrogen and keep playing until his estrogen level is back to what it was previously and see if there was any correlating loss of ranking.
Which is a shame. This is an untapped skill in games! I recall sniping in Metal Gear Solid had a steadiness mechanic. It used analog and rumble. You could even pop some diazepam to slow down your muscle twitching, as well as press a button to hold your breath! Very cool mechanics that other games don’t bother with!