New Hope in Alzheimer’s Fight: Researchers Identify Unique Early Biomarker
New Hope in Alzheimer’s Fight: Researchers Identify Unique Early Biomarker
This molecule is directly associated with the expression of the cellular prion protein located on the surface of nerve cells. The research, conducted by the Institute for Bioengineering of Catalonia, paves the way for early detection of Alzheimer's disease. A new study conducted by the Molecular
Clinical relevance of miRNAs as biomarkers is growing due to their stability and detection in biofluids. This study has identified miR-519a-3p as a potential early biomarker for Alzheimer’s, linked to prion protein expression. This molecule is directly associated with the expression of the cellular prion protein located on the surface of nerve cells. miR-519a-3p may potentially be used as a biomarker of preclinical stages of the disease.
https://www.sciencedirect.com/science/article/pii/S0925443924001765?via%3Dihub (open access)
In our study, we compared the levels of this biomarker in samples from other tauopathies and Parkinson’s disease, confirming that the changes in miR-519a-3p are specific to Alzheimer’s disease,” said IBEC senior researcher Rosalina Gavín, UB associate professor and co-leader of the study.
coooool!
This is important because because it's easily measurable, comparable, and likely to be unique. This was not the case with the Amyloid Plaque route of research (recently announced to be retracted due to falsified imaging in the original studies) where it could exist in non-Alzheimer patients in similarly measurable quantities. Takes a lot of the guesswork out.
Science fucking rules.