In Windows 10 & 11, window+shift+S then draw a box to grab a quick, pre-cropped screenshot. It goes to your clipboard for easy paste and you get a notification you can click to view and save to file.
Bonus: use window+L at work to lock your desktop, preventing shenanigans.
Changed screen orientation. The cursor indicated which part of the monitor was the top of the screen, so with a standard monitor config "Ctrl+Alt+Down" flipped the screen, for instance.