I'm not a scholar of the series or anything but I'm pretty sure you can die from an STD in the first game. I have a vague memory of finding a prostitute in the game and I had to reload my file. It's possible I'm misremembering a little and maybe you don't die, but it's a game over.
Depending on nature of the save in question, Minecraft could be pretty chill. Like a creative mode world is godlike power, a peaceful world would be a chill place where you can easily just build your own home to live in, and even a regular survival world isn't too bad given the respawns. Just as long as you don't choose like, hardcore or a pvp server world or such.
Assuming I’m equipped with the same equipment, I’d love to explore Horizon’s world. The idea of giant robot dinosaurs is just too cool to pass up, as scary as they are.