Some of the Scrubs jokes aged badly. I can't remember any specifically, but there was some anti-gay humor and stuff like that. The show I still appreciated enough to get through a rewatch recently and still mostly enjoyed, but some of the individual jokes were hard to sit through. Wish I could remember one lol.
Same with Futurama. Kif repeatedly reacting disgusted at Zapp's more homoerotic antics or singing a pro-trans song, do not seem to sit right when watched with a modern eye.