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Assimilating a single Zerg doesn't change the fact there is 10,000,000,000 more of them rushing in.
Okay, but The Borg have comparable numbers. Humans are Species 5618 when the Borg make first contact. That's 5617 species they have assimilated (or, at least, tried to assimilate) beforehand.
In Voyager, the whole Delta Quadrant is teaming with Borg. Functionally on par with the Zerg.
Identified for sure, not necessarily assimilated. Can't remember who the moment but there are people who the borg ignored because they were uninteresting. But there are species the Borg have identified and not assimilated as well
Kazon, for sure. "not worthy of assimilation"
Borg can’t match the lifecycle speed of Zerg though. Yes, they can create new infants, implant them, and accelerate their growth in maturation chambers to produce new adult humanoid drones, but the process took 17 cycles (days). Zerg on the other hand produce new drones in a matter of seconds and new hatcheries in a minute or two. Within a single day they could multiply across an entire planet or overwhelm a cube.