I've always had a soft spot for Snac2.

By far my favourite option. Without snac2 and the ability to self-host it very easily, I would not be on the Fediverse today. Bonus points for the main developer being very easy to get in touch with, and very reactive when problems are reported.

Keeping in mind that I am not coming from Mastodon or Twitter. Snac2 is my first experience as an active contributor to the Fediverse and more generally to micro-blogging.