I haven't started working on a game yet. It's a near future goal. I hope y'all are okay with me answering this question despite that fact!
The FOSS ones:
Blender for 3D. I'm excited to see what I can do with the geometry nodes (somewhat similar to Houdini's workflow)
Inkscape for 2D/GUI
Aseprite for 2D pixel art (I have a game project that mixes 2D and 3D)
The proprietary ones:
RizomUV: Blender covers a lot of ground, but RizomUV is much more fun to use for UV editing
Reaper: This is what I'm familiar with and excited to use. It's been very stable for me as well.
Obsidian.md (Free for personal use): I might need to reconsider this one if I ever need to work with one other on a commercial game, but I use this for writing documentations that aren't tied to code, workflow organization, etc. Use it for a lot of non-dev related stuff too
I'm somewhat on the fence about this. Having the frameworks provide some of the functionalities built-in was pretty nice. Having some of that structural opinion to work off of meant I'm not wasting time just figuring out how to architect the whole thing from scratch. At the same time, I would prefer to stick with vanilla, so it's less overhead and perhaps, the debugging would be more straight-forward. Trying to decipher React's large error messages was irritating at best.