The only HUGE thing to consider is that the file system of MacOS by default case preserving, not case sensitive. So make sure don't have files named Abc and ABC in the same directory.

I used to use Emacs primarily in Linux, but lately I am mostly using MacOS (Hammespoon made it possible). I find them to be equivalent once you set the keyboard accordingly.

At the beginning of my init.el I set a variable to know the OS and Machine where I am running, and do conditional configuration based on this. That way I can separate OS related configs for each of them. I run the exact emacs configuration in my different computers with different OSs.

Learn to use homebrew and make sure the binaries your emacs config uses (if any) are present (at the beginning of your init.el). I find dependency management slightly easier in linux than homebrew.

Another issue to consider is that Unix utilities in MacOS are not the FSF ones (instead, they are from BSDs). This means that commands like grep have different parameters in OS X (but that is usually handled by the emacs packages, usually).