I ran Linux on a Zenbook Pro Duo. Fedora's KDE distribution was the only release I ever found that worked out of the box with both touchscreens as I'd expect. You'd think a big release like Ubuntu would work, but whatever they have set up for touchscreens is slightly out of whack. For example, touch and drag would select text instead of scrolling the page.

By default, your laptop might try to stay awake all the time. The second screen is treated as an external monitor, and there's a setting you can find in the configuration menu that forces the laptop to stay awake when an external device is connected.

Some other things to note. If you've got an older model, you might be able to find a third-party software suite such as this one that will allow you to use your laptop almost normally.

However, if your laptop is new enough, you might be unable to find any software (third party or otherwise) that supports the built-in features such as quick screen swapping, numpad, or turning off the lower screen. The lower screen is LCD anyways, so you won't get burn in. If you're worried about power, I've found that despite the lower screen being on full-time, Linux still doubled or tripled my battery life compared to when I ran Windows. I think the biggest immediate drawback is that you may not have any on-board audio due to a lack of drivers, though that might have been fixed in Fedora 40. I know they were working on that in the newer version of upstream Linux (which may not have arrived yet), but I haven't been following it. And finally, you won't be able to adjust the brightness of the lower screen without some configuration. Again, some of that might be mitigated if you can find some compatible and reliable 3rd-party software for your laptop.

I will say that despite all the limitations mentioned above, I still vastly preferred Linux to Windows. The battery life alone was enough to warrant the switch.