Pluto was discovered because the orbit of Neptune didn't match predictions, so astronomers decided that there must be a ninth planet out there. It was very close to where the math predicted it would be.
It turned out later that Pluto was much, much smaller than at first thought, and couldn't be the 9th planet. It then turned out that the mass of Neptune was greater than expected, and the orbit actually matched expectations without the need for a 9th planet.
I took a smoking flight once. It totally reeked. Even as a smoker it was unpleasant. I also smoked in my hospital room after an appendectomy, which in hindsight seems absolutely nuts.
I quit 12 years ago after trying dozens of times. I credit e-cigs with helping me finally wean off of tobacco.
Why is Whitmer right out? I'm in Michigan, so I may not have a good perspective on what the rest of the US thinks of her.
As a kid in Detroit? Distant gunfire, most summer nights.
Now as an adult in the suburbs? Usually a fan, because my wife prefers that and I don't mind.
What a flock of raging assholes. How did they justify forcing working conditions like that on you that you clearly did not want? Did they offer any excuse for doing that?
Is this more of an ADHD thing, or an ASD thing?
I don't like bright overhead lights, either. I was diagnosed ADHD at the tender age of 56.
A couple of people mentioned Linux. I switched my main laptop to it 2 months ago. (Mint, specifically.)
I use it for work (office apps, chat apps like slack and teams, XMind, Joplin, TickTick), to play BG3, and some light programming in Python. It has been my daily driver at a new job (SE director), and I never use the Macbook they sent me.
Yes. I've been told that by cops in prior years.
That said, things have improved enormously in the last 10 years. There is a vibrant downtown area, and fairly large pockets of redevelopment around it, with safe(-ish) and affordable housing.
As a Detroiter, I think I really need to watch this.
I think most Americans like the idea of public transport, and including a robust national rail network. The reason it doesn't exist are the oil and automotive lobbies. (Mostly oil.). Poorly educated Americans (the ones wearing MAGA hats) are easy to manipulate by these groups, as well.
I was diagnosed at the age of 56. It might be worth you trying meds again. I have found Strattera to be extremely helpful to me.
And I followed every productivity guru in the world for decades just to try to keep things going for myself professionally. I have so internalized that I am just lazy and need to rail on myself to keep myself in line, that even though I know it isn't true I still do it to some extent.
I don't notice anything else related to vasoconstriction. My BP hasn't changed since I started on it, for instance. It doesn't really affect my appetite for sex, just my ability. This has lessened over time, but it's still present. (And after ~8h, everything is fine.)
You can take it before bed if you like. Some people find it sleep-inducing at first. I find it simulating an hour or two later.
From what I have read, there are several different experiences from it. You'll likely have to try it and see how it works for you, and what accommodations you'll need to make. Hopefully the comments in this thread give you an idea of what to look out for.
Yes, its daily. It took a few days to notice a difference for me, but it definitely helps me with executive function. I'm up to the max dosage after 18 months, but it's still working.
Side effects for me are nausea for maybe an hour after I take it, and major "shrinkage". Sex is a real challenge for around 8h after taking it, and it looks like I've been swimming in the Arctic sea for about that long. This isn't a major problem because I take it in the morning, but it has been occasionally frustrating. That effect wears off by evening, though, so my spouse is ok with me taking it. 🙂
I have never taken stimulants, so I can't offer a comparison there.
Enough that I can code in pretty much anything. I think the typing point was when I coded professionally in my 4th or 5th language some time in the early 90s.
A realistic take on rescheduling
It's a step forward, but there is still a long way to go for full legalization.
Is there a good source explaining how these drones are used in the US by the Chinese govt? Are they sold to consumers, but upload to a China-based cloud? There was zero background in that article.
I have been told (by my attorney) that arbitration is sometimes more expensive than filing suit. IIRC, the rationale is that arbitration can have very high fees and involve a large number of people. It was in the context of drawing up a boilerplate nda, but it has been awhile and I don't remember the details.
As more people are eating healthier diets, CNBC worries that it will cut into the profits of purveyors of unhealthy foods
The findings add to concerns that GLP-1s could take a bite out of the bottom lines of some of the biggest restaurant companies and packaged food makers.
Given the popularity of these medications, it's still amazing to me that we don't see more articles about how it has changed the lives of many people. Nor have I seen much about how traumatic the shortages can be to people who have longed for positive results in their weight loss journey for years, only to have that hope taken away by an inability to obtain their medication.
I keep seeing this showing up in memes. Was there anything particularly interesting actually being shown to her? Her expression is pretty funny.
I've tried paid versions of ChatGPT, Claude, and Gemini. I am currently using Gemini, and it is working reasonably well for me.
I mostly use it to replace searches. I haven't used Google in years, but mainly relied on DuckDuckGo until SEO made it less useful. My secondary use case is for programming. I tend to jump around to a lot of different languages and frameworks, and it's hugely helpful to get sample code describing what I want to do when I don't know the syntax.
Once in a great while, I will have it rewrite something for me. That is mostly for inspiration if I want to change the tone of something I wrote (then I'll edit). I think that all of the LLMs suck at writing.
A community for people using GLP-1 medications for weight loss
Discussions about weight loss, challenges and victories (on the scale and otherwise) using GLP-1 medications.
Check out Zepbound at lemmy.world.
This is a community for anyone who is using or plans to use Ozempic, Zepbound or any of the other peptide-based obesity/diabetes drugs. Share information, hacks and get support!
Shortage problems?
Has anyone had luck in getting their medication recently? My local pharmacy substituted a box of Mounjaro for me. (It's also tirzepatide, just marketed for diabetes instead of obesity.)
AI, regulation, and lessons learned from the current state of big tech
Unlike the risks from AI’s capabilities, the economic risks from new technologies are knowable and can be mitigated
A cosmology without dark matter
I haven't found anything calling this crank science, although it does make some rather sweeping claims. One is that dark matter does not exist, and another is that the universe is 27 billion years old.
https://phys.org/news/2024-03-universe-dark.html
Crisis in cosmology? Or just tweaking models?
I have read several articles like this one.
https://www.livescience.com/space/cosmology/james-webb-telescope-confirms-there-is-something-seriously-wrong-with-our-understanding-of-the-universe
They all seem to be saying that there is a "crisis in cosmology", where different measurements can't reconcile what the value of the hubble constant is.
Then I watched this video last night that seems to be saying it's all just tweaking different models.
https://youtu.be/2pux7v9qJ58?si=ux3zBSHR-vvsz9qY
I'm not entirely sure if they're talking about two slightly different things. (Hubble's constant, and the predicted age of the universe.) Or if the "crisis" is really just a misunderstanding, or just clickbait tactics. Any informed opinions on the subject?
A newly-discovered volcano on Mars
A deeply eroded giant volcano, active from ancient through recent times and with possible remnants of glacier ice near its base, had been hiding near Mars’ equator in plain sight. Its discovery points to an exciting new place to search for life, and a potential destination for future robotic and hum
Some useful information
This seemed quite informative & a way to kick off some conversation, so I’m crossposting from Reddit’s /r/zepbound sub.
I have worked on this over time in the Mounjaro sub but thought I would post it as it might help a few people.
These are not set rules, but rather a guide that has been found helpful by myself and others. In the early stages of taking the drug, the following steps may prove to be helpful: Taking the Medicine
Wait several weeks after picking up the prescription prior to starting. This will give you buffer for supply shortages in the future. These are very real and very impactful so while not required this is highly recommended. Go buy the OTC meds listed below in the side effects. These are for just in case they are needed. Store your pens in the box and keep inside your refrigerator. Remember vibration, light, extreme cold or heat above 80 degrees Fahrenheit will reduce the effectiveness of your drug. Read the booklet inside the box before you do anything. Seriously read it! Be intentional about selecting your shot day. For example, doing it on a Friday means experiencing maximum effect over the weekend when tendency to indulge is typically high Re: selecting injection day. Or, you may wish to inject on a Wednesday or Thursday if you experience side effects for a day or two after injection. (so, by the weekend, you’re feeling great and hunger suppression is still strong enough to counter any temptation to over-indulge) Make a choice that works for your life. If you need to move your shot day you may do so as long as you don’t take two doses in under 4 days or more than 14 days apart. Under 4 may result in too much medicine in your system. Over 14 days and Eli Lilly recommends starting over from 2.5mg. Either way consult your doctor prior for either scenario. Select an injection site location and be sure to rotate between several locations. The injection is hardly noticeable but if you let the pen come to room temp for 30 minutes prior to the shot you will not get a burning sensation from the cold. If the pen malfunctions or you have any issues / questions post injection then call Eli Lilly ASAP. Number on the box! KEEP THE PEN. Don’t discard as Eli Lilly may offer to exchange the pen. Process a refill as soon as you use pen #3 in each box. Note: If you have a prescription that allows for a 3 month supply then get all 3 months. This will help you manage through potential shortages.
Lifestyle Changes
Drinking 32oz of water three times a day helps regulate digestion. Incorporating lean meats and green vegetables in meals provided essential nutrients and fiber while protein helps alleviate tiredness, and vegetables regulated constipation. It’s advisable to minimize fat, sugar, and carbs during this period for better results. Purge your house of highly processed or sugary foods, and avoid artificial sweeteners as they interfere with the medicine’s glucagon impact. Pick a weigh-in day and maintain regularity. Don’t be surprised or discouraged by stalls that occasionally last weeks or even a month as they are normal. Aim for slow, healthy weight loss of around 2 pounds per week. Track calories and macros using an app of your choice. Use this journey to change the way you eat, learn about your nutritional needs, and focus on eating healthier, decreasing the loss of lean muscle mass. Get into a fitness routine or some sort. This does not have to be drastic are rigorous but again success with Mounjaro is about changing your lifestyle and health trajectory of which weight loss is just one key metric.
As Your Journey Progresses
Be ready to titrate up but not too eagerly. One does not have to get to 15mg unless their doctor advises otherwise. Work with your doctor to find the correct dosage, and avoid rushing to the top. This also helps keep weight loss in the 2lb range, preventing loose skin, hair loss, and other side effects of rapid weight loss. Start planning for what life looks like at the end of the weight loss journey. This process is called maintenance, and it is vital to keep sight of what happens afterward. It’s essential to avoid being a statistic and gaining back 80% of the lost weight. Regularly test your fasting Glucose, A1C, blood pressure, heart rate and cholesterol panel. This may be needed in the future to support insurance claims or future PAs.
Managing Side Effects:
Taking Pepto as needed may help reduce (sulfur) burps. This may turn you tongue black which is normal. Taking a Pepcid Complete as needed may help alleviate heartburn. Taking Imodium as need for for diarrhea. Taking stool softeners as needed aids with constipation early.
Note: Some people have no side effects and some people have a lot. Each person is different. If you don’t have indigestion, don’t the med but have it on hand. Some people have diarrhea instead of constipation, so be prepared but see if you have a side effect before assuming you will have it and taking another medication. Don’t be afraid of side effects or giving shots or any of the other fear thoughts that are stopping you from opening that box and changing your life. You got this!
A podcast with some useful information
From a doctor in an online obesity clinic. They have a lot of clinical experience with semaglutide and tirzepitide. This is a link to their online practice. (Note that I am not a member or affiliated in any way.)
For the podcast, you can search "Beyond the Scale with Dr. Spencer Nodolsky" in your favorite app, and it's available on YouTube as well.
I have listened to several episodes, and keep coming across interesting tidbits from their clinical practice. It isn't entirely focused on GLP-1 medication, but you can pull out the ones with "GLP-1" in the title. It looks like they have been on a break since November, but they were using all of the current GLP-1s in their practice as of last Oct-Nov.
A few perspectives I have picked up from listening:
- It is important to eat enough on these meds. It's healthier (from a psychological change-your-relationship-to-food perspective and from a physical health perspective) to get good nutrition and lose weight at a sustainable pace of <= 1.5% body weight per week. Use the med to help you eat smaller portions and avoid snacking, not to avoid eating all day.
- "Food Noise" reduction is a thing for most people they've seen. Although none of the meds were on-label for binge eating disorder, they have found that GLP-1's are an excellent treatment for that, and they tied it to "food noise".
- Most of the advice I've seen in this subreddit for side-effects is covered, and they offer some additional details, so worth a listen.
- They have seen both ends of the bell curve with hypo-and-hyper-responders to the meds. They usually try a different med to resolve that, but insurance can be a hassle in that case. Worth a listen if you are seeing good results with 2.5mg, or if you're titrating up & results are still suboptimal.
I have only listened to a handful of episodes, but they have all had useful information. If you listen to podcasts (I like them while doing housework or working out), I recommend this one.
Increase in DOMS?
Another of my posts from Reddit in recent weeks:
Does anyone else experience an increase in DOMS (delayed-onset muscle soreness) after starting zepbound? I have ramped up the intensity of my workouts lately, and it seems like muscle soreness has gotten much worse.
I'm thinking I should dial it back a bit, because it is also stimulating quite a bit of appetite. Not really what I want when I'm trying to cut calories and weight. 🤔
Addendum: The consensus was that a lot of people experienced more difficulty completing endurance workouts, but not specifically weight training (which is where DOMS usually comes from).
This article discusses one of the most profound realizations I have had from using Zepbound
I knew weight-loss drugs would change my body. I wasn't prepared for what they would do to my brain.
...and here is what I posted on Reddit in January on this subject:
I feel less of a sense of shame about my eating habits now
For most of my adult life, I have held a core belief that I am just "weak-willed". My weight and eating habits were at the core of this belief. After all, eating is an intentional act - an effort of will. If you eat sugary carbohydrates, or just very large portions of anything when you're already overweight, it's just a failure of willpower, right?
Zepbound is changing that for me. The effect was immediate and dramatic in my first week using it. I wasn't hungry and felt full quickly, as expected. The surprise was that I didn't even think about food. I understood immediately what people meant by "food noise" abating when on a GLP-1 medication.
And that's what is causing this sense of shame to abate. If a drug can eliminate thought patterns that I have engaged in for 30 years, do those thoughts really have anything to do with willpower? I think not. I see those thoughts now as being purely physiological at their source, and people who don't (or rarely) have food cravings aren't stronger willed than I am, they were just fortunate in the genetic lottery.
It's a good feeling to drop that shame. Or it will be, when I can finally let most of it go. I have consciously and unconsciously carried this feeling around for decades. I'm still carrying some around now, even though the rational part of my mind is already convinced.
If you have felt ashamed of being overweight (and I expect that nearly all of us have), consdier what I'm saying, and see if you can cut yourself some slack.
Welcome!
I checked the other communities in this space, and they're completely inactive and (apparently) unmoderated. Since I'm a few months into this journey, and I love to really dig in to topics, I decided to create a community & see if others are interested in it.
You got a box of Zepbound - now what?
This seemed quite informative & a way to kick off some conversation, so I'm crossposting from Reddit's /r/zepbound sub.
I have worked on this over time in the Mounjaro sub but thought I would post it as it might help a few people.
These are not set rules, but rather a guide that has been found helpful by myself and others. In the early stages of taking the drug, the following steps may prove to be helpful:
Taking the Medicine
- Wait several weeks after picking up the prescription prior to starting. This will give you buffer for supply shortages in the future. These are very real and very impactful so while not required this is highly recommended.
- Go buy the OTC meds listed below in the side effects. These are for just in case they are needed.
- Store your pens in the box and keep inside your refrigerator. Remember vibration, light, extreme cold or heat above 80 degrees Fahrenheit will reduce the effectiveness of your drug.
- Read the booklet inside the box before you do anything. Seriously read it!
- Be intentional about selecting your shot day. For example, doing it on a Friday means experiencing maximum effect over the weekend when tendency to indulge is typically high Re: selecting injection day. Or, you may wish to inject on a Wednesday or Thursday if you experience side effects for a day or two after injection. (so, by the weekend, you’re feeling great and hunger suppression is still strong enough to counter any temptation to over-indulge) Make a choice that works for your life.
- If you need to move your shot day you may do so as long as you don’t take two doses in under 4 days or more than 14 days apart. Under 4 may result in too much medicine in your system. Over 14 days and Eli Lilly recommends starting over from 2.5mg. Either way consult your doctor prior for either scenario.
- Select an injection site location and be sure to rotate between several locations. The injection is hardly noticeable but if you let the pen come to room temp for 30 minutes prior to the shot you will not get a burning sensation from the cold.
- If the pen malfunctions or you have any issues / questions post injection then call Eli Lilly ASAP. Number on the box! KEEP THE PEN. Don’t discard as Eli Lilly may offer to exchange the pen.
- Process a refill as soon as you use pen #3 in each box. Note: If you have a prescription that allows for a 3 month supply then get all 3 months. This will help you manage through potential shortages.
Lifestyle Changes
- Drinking 32oz of water three times a day helps regulate digestion.
- Incorporating lean meats and green vegetables in meals provided essential nutrients and fiber while protein helps alleviate tiredness, and vegetables regulated constipation.
- It’s advisable to minimize fat, sugar, and carbs during this period for better results.
- Purge your house of highly processed or sugary foods, and avoid artificial sweeteners as they interfere with the medicine’s glucagon impact.
- Pick a weigh-in day and maintain regularity. Don’t be surprised or discouraged by stalls that occasionally last weeks or even a month as they are normal. Aim for slow, healthy weight loss of around 2 pounds per week.
- Track calories and macros using an app of your choice. Use this journey to change the way you eat, learn about your nutritional needs, and focus on eating healthier, decreasing the loss of lean muscle mass.
- Get into a fitness routine or some sort. This does not have to be drastic are rigorous but again success with Mounjaro is about changing your lifestyle and health trajectory of which weight loss is just one key metric.
As Your Journey Progresses
- Be ready to titrate up but not too eagerly. One does not have to get to 15mg unless their doctor advises otherwise. Work with your doctor to find the correct dosage, and avoid rushing to the top. This also helps keep weight loss in the 2lb range, preventing loose skin, hair loss, and other side effects of rapid weight loss.
- Start planning for what life looks like at the end of the weight loss journey. This process is called maintenance, and it is vital to keep sight of what happens afterward. It’s essential to avoid being a statistic and gaining back 80% of the lost weight.
- Regularly test your fasting Glucose, A1C, blood pressure, heart rate and cholesterol panel. This may be needed in the future to support insurance claims or future PAs.
Managing Side Effects:
- Taking Pepto as needed may help reduce (sulfur) burps. This may turn you tongue black which is normal.
- Taking a Pepcid Complete as needed may help alleviate heartburn.
- Taking Imodium as need for for diarrhea.
- Taking stool softeners as needed aids with constipation early.
Note: Some people have no side effects and some people have a lot. Each person is different. If you don’t have indigestion, don’t the med but have it on hand. Some people have diarrhea instead of constipation, so be prepared but see if you have a side effect before assuming you will have it and taking another medication. Don’t be afraid of side effects or giving shots or any of the other fear thoughts that are stopping you from opening that box and changing your life. You got this!
Have additional issues or questions about Mounjaro, please head to:
Mounjaro Website___