I've been looking at it after numerous times I update Fedora only to have some tool break that I use daily. Then I spend a chunk of the day getting Virtualbox working again so I can do my job (write code for websites).
I haven't made the jump, but it looks very interesting.
Conda and any other reproducible computing library that relies on LHS Linux filesystem just doesn't work on it (okay it does, but more as an obstacle)
I'm okay with having nix the package manager on my default arch system though, since it is incredibly useful for cross compiling, and it let's me modify my system however I want.
I also often put the "dirty" packaged AI/python stuff (which is unfortunately quite a lot) into Dockerfiles if I don't want to package it cleanly with Nix.