The stupidity of Redditors baffles me
The stupidity of Redditors baffles me
Rabies fucking virus don't fucking go undetected for 2 years at may nabasa pa akong 5 years daw tsaka umepekto ang rabies, comments are insane
1st reason: Natural Killer Cells can order a fucking cell to commit suicide if it looks stress, not even virus infected, JUST FUCKING STRESSED that's how paranoid it was. 2nd reason: virus multiply rapidly it's not like bacteria that multiply into 2, then to 4, then to 8, 1 virus can replicate to 10, it can replicate billions in day so every cell of his body should be rabies infected by now 3rd reason: death by shutting down of protein synthesis, the organelle that produces proteins is also the organelle that produces virus if a cell is infected by one, it won't be able to repair if a rabies is still present after 2 years 4th reason: since it's not possible for a cell to produce protein when virus infected, Killer T-Cells can see through inside of cell via MHC Class I if it produces proteins if a cell don't produce it will order it to commit suicide.
Kung totoo man yung 5 years na yon bago umepekto ang rabies, it's either the rabies virus that person contracted is abnormally slow for a virus or the person is incomprehensibly immunosuppressed and have incredibly strong cell membrane, or malnourished to the point that triggering an immune response will result on death so the body decides not to and chose to stay silent
comments are full of fake info argh!!!
if worried sya, dapat sa pinakamalapit na clinic na lang sya pumunta kesa post sa internet. Sigurado ma-educate pa sya ni doc ng additional info para makampante sya.
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if I understood it correctly, the transmission of rabies from bite site to the brain is not completely understood
you just said it step by step, but to add more details rabies spreads through circulation and population, to answer the question do rabies only targets neurons hard no, so before it reaches the head it does it things, replicate and destroy its targets, and that will trigger an immune response kung wala man symptoms of rabies the infected cells will probably release pyrogens and inflammatory cytokines at dito na mapapansin ng victim na merong something mali sa kanya at pag nagpa doctor siya maaaring ma-advisan siya na baka nga dahil sa rabies, those subject to research probably lie or lacking self-awareness that something is wrong with their body since rabies virus if outside the cell will be detected by complement proteins and if inside of infected cell will be detected by KTC and NKC, maiintindihan ko pa kung bacteria eh since bacteria have a mechanism called quorum sensing which is their way to hide when in danger cause by antibiotics or immune response
Also Rabies Vaccine is a Vaccine not a medicine, that person's body produced immune cells, antibodies, complement proteins right now without getting vaccinated if it's that long already
There are cases nga na lumalabas yung symptoms after a year. Sa pagkakaintindi ko kasi depende sa location ng wound, severity ng wound or baka konti yung viral load na na-introduce sa katawan. Kapag ang kagat ay malayo sa ulo or utak, mas matagal ang symptoms, yan turo ng prof ko noon sa virology.
Nagpa-antirabies ako 2 years ago. Sabi nung doktor, effective daw yung shot up to 2 years. Pero kung nakagat sa collarbone pataas, kailangan magpa-injection ulit.
Kelangan ang booster shots if nakagat ka uli, regardless sa kung saan ka nakagat. At least yun ang sabi dun sa bite center nung nagpa-turok ako last year. Ang pinagkaiba lang is for two years di mo kelangan yung 4-shot series, booster lang. After two years at nakagat ka uli, start from zero ang injections.
I've questions for you, does the further to brain the higher the survivability? I have a guess yes since the immune response will prevail over rabies virus, it's not as smart as Kurzgesagt portrays it to be rabies virus action is actually frankly messy, I've also watched Kurzgesagt video on rabies it said that neurons can shut down an immune cell but ChatGPT said otherwise here's the list of cell from our body that can shutdown an immune cell based on ChatGPT (Cytotoxic T cells, Natural Killer (NK) cells, Macrophages, Regulatory T cells (Tregs), Dendritic cells (DCs), B cells, Endothelial cells.
Here's what I asked ChatGPT on Kurzgesagt claims that a neuron can shutdown an immune cell:
prompt: can rabies virus control a neuron to shutdown an immune cell
response: No, the rabies virus cannot directly control a neuron to shut down an immune cell. Rabies primarily affects neurons within the central nervous system, leading to neurological symptoms and ultimately death. While the virus can indirectly impact the immune system through its effects on the nervous system, it does not have direct control over immune cells. During a rabies infection, the virus primarily targets neurons and spreads within the nervous system. The virus hijacks the cellular machinery of neurons to replicate itself and spread further. As the infection progresses, the immune system responds by mounting an immune response to eliminate the virus. The immune response against the rabies virus involves the activation of immune cells, such as T cells, B cells, and macrophages, to recognize and eliminate the virus. The immune cells interact with infected neurons, attempting to clear the virus and control the infection. However, the rabies virus has developed mechanisms to evade and interfere with the immune response. It can manipulate certain host proteins and interfere with the production of antiviral molecules, dampening the immune response and allowing the virus to persist within neurons. While the immune response can play a role in clearing the infection, the ability of the rabies virus to evade and interfere with immune cells can contribute to the progression of the disease and its evasion of immune defenses. Therefore, while the rabies virus can affect immune responses indirectly through its impact on neurons and the nervous system, it does not have direct control over immune cells to shut them down. The complex interactions between the virus, neurons, and the immune system contribute to the pathogenesis of rabies.
viral load doesn't matter since viruses are able to replicate faster