Microsoft is now in the process of turning off Manifest V2-based extensions in Edge, such as uBlock Origin. However, not everything is lost at this point.
I won't lose much myself as I don't use Edge (and I'd rather not browse the web at all than be forced to look at ads) but it's clear there is a worrysome acceleration in the vanishing of the little control we have over the Internet and the way we are allowed to experience it.