In general, not enough research is done on longterm health, especially since maintaining longterm access to healthcare can be difficult for many. but here is one study on it: https://pubmed.ncbi.nlm.nih.gov/38662108/
as for something i have personally experienced, i didn’t expect it to physically get harder to create tears when i felt like i was gonna cry. been on t for almost 15 years now. it’s gotten a little easier but still not anywhere near as easy as when i was young.