Colonist // Sole Survivor: Shepard has lost everything, twice. Come out of the unlikeliest scenarios consistently.
This gives them a pragmatic view of survival and a chip on their shoulder for Batarians and Cerberus. Seeing the way people have been mistreated, Shepard goes out of their way to help those that are genuinely in need while mercilessly fucking up anyone who is causing suffering to others. Always betray Cerberus, tell TIM to fuck off in every possible scenario, probably a little prejudiced toward Batarians.
So Paragade, basically. 60/40.
"Lot's of ways to help people, sometimes heal patients, other times kill dangerous people. Either way helps." -Mordin
Paragade Shepard Shepard is a pretty strong playthrough. My Shepard tends to be a bit more diplomatic with TIM until the crew gets thrown into the truly shitty situation on the Collector ship and EDI says the Illusive Man set us up. Yes, we got the data but Shepard stops being nice about going along with TIM.
That's how I play it when I don't do sole survivor, knowing the evils they did in ME1 makes it difficult but I'll give TIM the benefit of the doubt until he throws me into the situation and lies.