TERT activation targets DNA methylation and multiple aging hallmarks
TERT activation targets DNA methylation and multiple aging hallmarks
TAC promoted tissue rejuvenation, including new neuron formation, and alleviated multiple aging hallmarks in aged mice, revealing the regenerative potential of adult tissues through physiological TERT activation.
This work using high-throughput combinatorial chemistry to find molecules to stop/revert aging is amazing. I have been looking it in the past few days. The authors screened 653,000 different compounds, I am very curious about how expensive this screening was.
I was not aware of DePinho but I am familiar with Schultz's work. I thought that would get a Nobel prize for his work on non-canonical amino acids, but he hasn't yet. I am now placing my bets, Ronald DePinho and Peter G. Schultz will win a Nobel prize.
Certainly an interesting study. I hope we get to hear more about it soon, and hope their work is followed up on
Are they intentionally not naming or describing the TAC?
The structure is shown in the full text:
It really seems like it.