The Great Filter is the idea that, in the development of life from the earliest stages of abiogenesis to reaching the highest levels of development on the Kardashev scale, there is a barrier to development that makes detectable extraterrestrial life exceedingly rare. The Great Filter is one possible resolution of the Fermi paradox.
The Fermi paradox is the discrepancy between the lack of conclusive evidence of advanced extraterrestrial life and the apparently high likelihood of its existence. As a 2015 article put it, "If life is so easy, someone from somewhere must have come calling by now."
Personally I think it's photosynthesis. Life itself developed and spread but photosynthesis started an inevitable chain of ever-greater and more-efficient life. I think a random chain of mutations that turns carbon-based proto-life into something that can harvest light energy is wildly unlikely, even after the wildly unlikely event of life beginning in the first place.
I don't think life is rare, nor photosynthesis, but complex life might be. A planet needs to be really thriving with life for it to be worth it to go down the path to something like animals
But I think the bigger filter is much stranger.
Humans are a hive-like species. We're not just social - we're insanely interdependent, we don't function on our own and yet we've ended up in this place where we (often) try to individually succeed, even at the cost to our community
We're greedy enough to want the stars, yet interdependent enough we could only swarm over them in endless numbers
There's many problems with the fermi "paradox", but personally I think one of the largest is assuming all species would spread like a cancer blotting out the stars
A more individualistic and long lived species might instead be careful explorers, taking what they need and leaving little sign of their passage. A more communal species might be careful and control themselves to not destroy pointlessly. They might also feel no desire to contact other species
We're just the right mix to want everything a star could give, and to want to find others at great energy cost
Prometheus didn't gift us fire and cognition. Lies. We are Prometheus's curse on the universe. Nothing more than a plague on the gods creation, concocted for some slight we can never understand. The sum of us, brought into being, then tossed into the void and forgotten. To spread like an oil stain across creation.
"And behold, I Myself am bringing floodwaters on the earth, to destroy from under heaven all flesh in which is the breath of life; everything that is on the earth shall die." - Genesis 6:7
"If you had not committed great sins, God would not have sent a punishment like me upon you." - Genghis Khan