Grab the "2 random pills" and the "duplicate anything you own once" pill. Duplicate the "2 random pills" pill with the duplicate pill and eat both "2 random pills" pill and have 4 absolutely random abilities.
“2 random pills” and shoebox pill. Take the shoebox pill, get a shoebox filled with the 2 random pills (since you got one they became “real”). Grab a big handful of pills and swallow.
Others (in case you don’t want to collapse civilization or piss gasoline):
Shoebox + any question = practically unlimited questions. Plus the first one should be something like “how can I achieve maximum happiness (in an easy way where current me would be comfortable with the results)?” and you can ask variations to get a clearer answer since you have practically unlimited ones. Only drawback is if “single-use” really means the duplicates don’t do anything.
Shoebox + groundhog day = probably get to live >10000 years (unless “single-use” prevents that)
Shoebox + pi money = practically unlimited money, no “single use” issue
So what would shoebox + collapse civilization look like? Meteor storm of world ending asteroids? Collapse all civilizations for the next 10000 years? Start destroying alien civilizations?