The cards will be a higher power level and more impactful, as they skip standard.
Plus if it's anything like MH2 it'll totally shake up the meta and change which decks are played, so also invalidating previous wildcard spends.
Unless you want to focus on Explorer, which won't be affected. In which case... Ravnica sets for a chance on a shock land and NEO for an above average pool of playable too (IMHO) would be decent choices.
That sounds lit! I only draft sets I like the limited environment of (not many), but if it has a nice balance of archetypes and isn’t too Grundy I’ll probably do that.