misuse can seriously fuck up windows. Disabling things that shouldnt be, is bad. Many of the services are required by other aplications to run. Do not disable any Microsoft services you dont know what they do - otherwise disable as many as possible until the computer stops working.
If you can not read or just want to uncheck everything you see, this is not for you:
There's definiaty some you can and should be disable, but I'd use O&O for that.
Unless you actually know what each service does, its best to leave them alone.
Ya know any services that can be disabled in general and how to safely turn them off and back on if something doesn't work? I hate how Windows Services eats up so much of my really powerful computer.