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Personally, I'm a huge fan of glitch-soc (Mastodon fork). I previously used CalcKey and HajKey but never IceShrimp so maybe the Misskey forks are onto something.
For me it came down to a simple physical limitations that some interfaces show too much information at once and it's mentally overwhelming. This is a highly specific issue, hence why I just switched to glitch instead of trying to make a Misskey forks that fits my needs.
In terms of feature-set and "coolness" I have to give it to the Misskey forks. Though I've never tried Akkoma so IDK what it feels like. The features out of CalcKey were pretty awesome and I kinda wish I could use an instance with those features.
I'm a pretty specific case where my "daily driver" per se is out of accessibility reasons and not feature set. I adore the features of CalcKey but I have to use a simpler system like Mastodon. And luckily the glitch-soc instance I'm on is running a custom fork with additional features like emoji reacts and such. So it is pretty far away from "vanilla Mastodon"