Something I've always noticed and am going through now. Sometimes I'll drink too much the night before and be concerned about a hangover the next morning. Morning comes, and almost always my first thought is "gee I feel like shit but actually this is way less bad then I was expecting" this misplaced optimism gets washed away at an indeterminate length of time later when a wave of awful nausea crescendos to a peak of crappiness before gradually receding leading me to think "maybe that was the worst of it" only for the cycle to repeat.
This happens even when the hangover is not one severe enough to have caused vomiting. Feeling sick from drinking too much I understand, but I wonder what's physically happening during the peak of these waves that's not happening during the troughs.
Once the source of the hangover headache was located, the researchers then set about figuring out how to get rid of the pesky things, using known headache blockers. Turns out the combination of caffeine and over-the-counter inflammatory drugs (i.e., NSAIDs – things like aspirin and ibuprofen) were best at blocking the head-pounding effects of the acetate.
Although as with everything, timing is crucial.
“If you drink a small amount of alcohol, three or four hours later, drink some coffee,” he says. “Or take caffeine in some form, like an Excedrin that has caffeine in it. If you take the caffeine at the same time as you drink, it will be gone when the acetate levels are high.