Yeah, I'd still go creepy (how can a universe that allows billion year old starlight not be, looked at viscerally?), but I'd try to do it in a way that makes you wonder if the human perspective is necessarily the right one. Lovecraft has a way of including all kinds of adjectives to make you know how you're supposed to feel. He had (ahem) strong feelings about unfamiliar people and practices in real life, so it was kind of inevitable.
Come to think of it, Parasyte had some of the same energy I'm picturing.
There's degrees you can go to with this, though. Lovecraft is a philosophical pessimist in his Mythos, while the other main take on "the absurd" is the Existentialist one, where the lack of meaning is an opportunity to be treasured. I land right in the middle, personally.
Lovecraft redid the deluge myth, in a way, with his Great Race of Yith. God brought a world-ending calamity (more than once), but this time for no specific reason, and saved nothing each time, because why would he when our world isn't important?
He basically just doomers about this, so it's horror. An Existentialist work might have the characters pass up an opportunity to stop it, because the cycle of destruction is a good thing and needed for the Cleopterans to evolve and have their day in the distant future. I'd take more of a survive-in-spite approach, so maybe there's a secret society of astral projectors across the eons, who make a living by leaving relics for each other in long-lasting caves. It's not good that the world keeps ending, but it brings silver linings too, and we make our way in life none-the-less.
Sadly, once the world building ends I'm clueless about building a laying out a narrative that doesn't suck. I'll have to see where Ada Hoffman goes.