They just kept hitting you with more "holy shit" moments after you recovered from the previous one. The cameos, good lord I was not ready for them. Peter was in it, so it was obviously going to be good.
"... But Disney is."
"Your tailor is a predator."
"He's going to say it!"
"Who was your dialect coach?"
Mary Poppins
They really are going to need maximum effort to top the next one.
Deadpool is owned by Disney, they will make more because it made $96 million on the opening day and Disney loves to make money.
I doubt Jackman will come back for another one, but he certainly loves money and seems to have fun working with Reynolds, so maybe he will put on the suit again.
Reynolds loves money and loves the franchise. He will absolutely do another one, even if he isn't in front of the camera. He definitely wants to do cameos in other Marvel movies, but I expect that to be background gags or brief scenes instead of featuring.
Honestly, they should. The Marvels was massive flop. Johnathan Majors is out (this hurt bad). Blade is coming out , eventually. Who knows about Tom Holland's spider man.