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What book is it that tries to scientifically explain vampires? It talks about why vampires don't like crosses and it's because of some irrational fear of symmetrical geometry or something. In other words it has nothing to do with religion, according to that book's mythos. I thought it was a neat alternative take on the genre. Iirc it was a sci-fi book.
Edit: I looked it up, the book I was thinking of is called Blindsight. I believe the reasoning they provide in the book is that due to their unique spatial reasoning, too many right angles give them seizures.
That was from the Castelvania show.
However I Am Legend is probably one of the first books to explain to explain vampires in a scientific rather than a magical way. In that it was psychological and they only hated religious symbols from the faith they had in life, and I believe that only applies to "undead" vampires and not living ones.
I Am Legend is a fantastic book, but not what I was thinking about. I looked it up and it was actually Blindsight I was thinking of. Regardless, I always recommend people read I Am Legend, it's a lot different than the movie (which I also enjoyed).
Doctor who has an episode about vampires that basically boils to they're aliens. https://tardis.fandom.com/wiki/Saturnyn
In some books, I'm thinking of Dresden Files, I think it has less to do with the faith of the vampire and more to do with the faith of the person using the symbol. With Dresden, he uses a silver pentacle that his mother gave him and it has the same effect.
I don't know which book you're thinking of but this is touched on in the Castlevania show: https://youtu.be/ozID5sgofno?si=WmKK_FCgOcc08E4P
This video gives a biological explanation to vampires that explains their aversion to right angles as well: https://www.youtube.com/watch?v=oJLA8iNUV-0