Most games installed on my main OS drive refuse to launch. Proton issue or something else?

It seems to mostly happen to 3D games, very rarely for 2D ones.

Normally, this wouldn't be much of an issue for me since I install everything to secondary SSDs anyways, but the one piece of software that is driving me up a wall is Steam VR, since its installation folder can't be moved.

I could find plenty of fixes when it came to the opposite problem (launching games from another drive) but nothing for my situation.

Any solutions or even just point me in the right direction where to start when it comes to troubleshooting something like this?

OS: Endeavour OS

GPU: RTX 2070 (latest Nvidia drivers)

CPU: Ryzen 2700X

Happens on both X11 and Wayland environments and everything is up-to-date

Edit: also this seems to happen with every version of Proton