Sensory hypersensitivity in mice with Grin2b mutations is associated with hyperactivity in the anterior cingulate cortex and increased connectivity throughout the brain. A research team led by Director Kim Eunjoon of the Center for Synaptic Brain Dysfunctions and Director Kim Seong-Gi of the Center
This study has identified the anterior cingulate cortex (ACC) as a key area in the brain responsible for sensory hypersensitivity in autism spectrum disorders. Utilizing a mouse model with a Grin2b gene mutation, heightened neural activity and connectivity in the ACC was observed. Suppressing this hyperactivity normalized the sensory hypersensitivity, offering new insights into treatment options
ACC is mainly studied for its role in cognition and emotion. In the article linked it's mentioned >The ACC is one of the higher-order cortical regions that have been extensively studied for cognitive and emotional brain functions, but have been understudied for brain disease-related sensory abnormalities.>
I also found another article on the role of ACC in cognition and emotion: https://neuro.psychiatryonline.org/doi/full/10.1176/jnp.23.2.jnp121