I'm not too deep into noita myself, but I know a lot from watching furyforged. Do you still just take the route down to kolmi, beat his ass and win or do secret stuff every run?
I generally take the standard route until about the jungle or so. I keep my eyes open for wands+spells able to dig through holy mountains, teleport wands, and wands capable of bringing down bosses like Squidward and others. If I find them, I jump the rails and go do other things, if not I focus on just beating Kolmi. I generally can take the first option 1 time out of every 5-6 tries, though I am sure I could do it more often if I was better!