I think you're going to get a wide variety of responses here. It comes down to a lot of factors.
For me personally, I've been shifting everything I have to Btrfs, so I can tell you what I've done recently and why.
A big caveat is that many of my systems have multiple physical drives. This means I'm often setting things up based on the speed and capacity of those disks.
But, I do have one system with a single drive shared for booting, root, and home. It's set up like this:
A FAT32 partition for /boot. 512 MB.
A single Btrfs partition across the rest of the drive.
Btrfs subvolumes: @ mounted at /, @home mounted at /home. @snapshots mounted at /.snapshots.
I could go crazy with other subvols (e.g. for /var/log), but ultimately it is sufficient for me to be able to snapshot / and /home separately.
For some of my other systems, I'll have / and /home on different drives. In that case, each has their own @snapshots with their own mount point. I tend still to throw the EFI boot partition mounted at /boot on the same drive as /.
It's very easy to simply change /etc/fstab as needed and point to another snapshot, effectively rolling back the drive to some former point as necessary.
Fair, I've not had any issues but I'm sure they exist. One or the other is faster based on workload, too, so it's not really that one is objectively better all the time.
I'm sure a lot of them existed 10 years ago but today it is a really good FS. I'm using btrfs on my server and laptop for a few years and had 0 issues. Today's opinions on largly btrfs base on bugs and FUD from the past which is a shame.